Abstract
Cytogenetic analysis is currently a standard prenatal diagnostic test. It is routinely offered to pregnant patients who have an increased risk of carrying chromosomally abnormal fetuses. The traditional “gold standard” for prenatal diagnosis of chromosome abnormalities is metaphase analysis by G-banding. The primary advantages of standard cytogenetic analysis are the ability to detect aneuploidies as well as structural chromosomal aberrations with great accuracy (<99.5%). Traditional karyotyping, however, requires isolation of metaphase chromosomes from cultured fetal cells and therefore is time consuming. Although reporting time has decreased dramatically during the last 3 decades, conventional karyotyping still requires 7–12 d of which culture time is the most time consuming ().
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
