Internet-Delivered Lifestyle Physical Activity Intervention Improves Body Composition in Multiple Sclerosis: Preliminary Evidence From a Randomized Controlled Trial

Abstract

ObjectiveTo examine the efficacy of a physical activity behavioral intervention for improving outcomes of body composition in persons with multiple sclerosis (MS). DesignSecondary analysis of data from a randomized controlled trial. SettingUniversity research laboratory. ParticipantsAmbulatory persons with MS (N=82). InterventionA 6-month, internet-delivered physical activity behavioral intervention designed to increase lifestyle physical activity, primarily walking. The behavioral intervention was based on principles of social cognitive theory. Main Outcome MeasuresWhole-body bone mineral content (BMC), bone mineral density (BMD), and soft tissue composition, using dual-energy x-ray absorptiometry. ResultsThere were no significant differences between conditions posttrial on body composition outcomes using the adjusted critical value (P<.008). There was a significant effect of the intervention on whole-body BMC (P=.04, ω2<.001) and BMD (P=.01, ω2=.003) using the unadjusted critical value (P<.05). The effect of the intervention on percent body fat (P=.09, ω2=.001) and whole-body fat mass (P=.05, ω2=.003) approached significance using unadjusted criteria. There was not a significant effect on whole-body lean soft tissue (P=.28, ω2<.001) or body mass index (P=.86, ω2<.001). ConclusionsOur results provide preliminary evidence that an internet-delivered lifestyle physical activity intervention might improve bone health and body composition in MS. Such findings are important considering that physical activity is a modifiable behavior with the potential to confer long-term benefits for the prevention and management of fracture risk and comorbidities among those with MS.