International Union of Pharmacology. LIX. The Pharmacology and Classification of the Nuclear Receptor Superfamily: Thyroid Hormone Receptors

Abstract

The initial identification of thyroid hormone receptors (TRs[1][1]) was based on binding studies ([Oppenheimer et al., 1972][2]). The TR main ligand is 3,5,3′-triiodo-l-thyronine (T3). T3 production primarily results from deiodination of thyroxine (T4), which is secreted by the thyroid gland. Most