Abstract
The authors analyzed the influence of ACE insertion/deletion polymorphism on susceptibility to SLE, development of nephritis and hypertension, other clinical features and autoantibody phenotype in South Indian patients with SLE. Three hundred patientswith SLE and 460 age and sexmatched controls of similar ethnicity were included. The ACE gene insertion/deletion polymorphism was analyzed by PCR. Insertion (I) and deletion (D) alleles were observed to be equally distributed among patients (57 and 43%) and controls (59 and 41%), respectively. Themutant (D) allele did not confer significant risk for SLE. There was no association of the ACE genotype or the allele with development of lupus nephritis or hypertension. The presence ofmutant allele (D) was not found to influence any clinical features or auto-antibody phenotype. This study provides important information about the genetic predisposition to the clinical manifestations of SLE in an Indian population. It is a valuable addition to the ongoing series of research into the genetics of SLE from JIPMER, Puducherry.
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