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Abstract
Described herein is a catalyst-free tandem imine formation/Mukaiyama-Mannich sequence of fluorinated silyl enol ethers and α-amido sulfones, allowing the efficient synthesis of value-added β-amino α-fluorinated ketones in good to excellent yields. Noticeably, the key for high efficacy of the catalyst-free reaction is attributed to the in situ generated acidic by-product PhSO2X (X = TMS or H) that can act as an promoter for the subsequent Mukaiyama-Mannich reaction.
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