Abstract
Medically unexplained symptoms (MUS) are a major medical burden and our current understanding of the pathophysiological process leading to their development remains minimal. While research has strongly linked chronic stress to the development of MUS the exact mechanisms and the reason for the many variations in the resultant symptomatology remain unclear. In this paper we advance the hypothesis that an internal (visceral) sensory gating system must exist akin to the much better studied external sensory gating system. The hypothesis is based on the observations that under normal conditions sensations of internal organs do not reach consciousness (i.e., filtered or gated out on a subconscious or preattentive level). As visceral sensations are usually perceived only when there is a pathological process affecting the organ, then failure of this internal gating system leading to the sensations arriving to consciousness must be interpreted by the brain to indicate pathology in this organ. If the hypothesis proves to be true and such a system does exist, the implications are many and significant including developing methods for assessing the system and possibly correcting it.
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