Abstract
The pronounced modifications in the bodily form and general growth reactions accompanying well known diseased conditions of the endocrine glands make it evident that the composition of the internal environment seriously affects the growth functions of the bodily tissues. The experimental modification of the internal environment through removal of parts of, or entire, endocrine glands frequently gives rise to growth alterations and characteristic deviations from the structural norm of the species. Such facts have impressed students of growth and development with the importance of the glands of internal secretion as regulators of structural expression in the vertebrate kingdom. On the other hand, invertebrate animals as well as plants entirely lacking specialized endocrine glands do, nevertheless, also show typical structural deviations and modifications closely comparable to those frequently attributed in the higher forms to the effects of altered internal secretions.
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