Abstract
The speed of sound (u)in conjunction with density (ρ) and viscosity (η) for amino acids l-glutamine and l-histidine in aqueous solutions of metformin hydrochloride (an anti-diabetic drug) (0.01, 0.07, and 0.13mol·kg−1) have been measured in the concentration range (0.02–0.20mol·kg−1) at (293.15, 298.15, 303.15, 308.15, and 313.15) K. In order to account for the consequences of drug–amino acid interactions, various acoustical parameters such as intermolecular free length (Lf), relative association (RA), specific acoustic impedance (Z), and molar sound number ([U]) have been evaluated from density and speed of sound data. Combined with viscosity values, the speed of sound data have been used to estimate parameters like relaxation time (τ), internal pressure (πi), molar cohesive energy (MCE)and free volume (Vf). The results of acoustical studies are substantiated with UV–Vis studies for ternary system (water+drug+amino acid). The different kinds of intermolecular interactions existing between different components of the mixture are found to be responsible for the varying trends in aforesaid different acoustic parameters.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
