Abstract
AbstractA new gold(I)‐catalyzed multicomponent synthesis of β‐alkoxy ketones from aldehydes, alcohols, and alkynes is described. This atom economical synthesis was achieved through the use of the gold complex (SPhos)AuNTf2 as a catalyst, and allows for the preparation of a diverse array of β‐alkoxy ketone products. Mechanistic studies illustrate that these reactions proceed via gold(I)‐catalyzed hydrolysis of the alkyne to an aryl ketone, which then undergoes an aldol reaction with an oxocarbenium ion generated in situ from the aldehyde and alcohol components.
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