Abstract
Flurothyl seizure threshold in rats is decreased by intermittent photic stimulation (IPS) or by intermittent sonic stimulation (ISS), or bilateral lesions of the visual cortex. However, when IPS and ISS are presented simultaneously, thresholds return to normal (control) values. Also, when visual cortex lesions are combined with ISS the threshold returns to normal values. These experiments corroborate past reports of sensory-precipitation of seizures. Furthermore, the data suggest that seizurogenicity is influenced not only by the interplay of environmental multimodal inputs, but also by the intermodal interaction of sensory inputs and focal brain damage.
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