Abstract
Purpose:To investigate the effect of intermittent vibration at different intervals on bone fracture healing and optimize the vibration interval.Methods:Ninety sheep were randomized to receive no treatment (the control group), incision only (the sham control group), internal fixation with or without metatarsal fracture (the internal fixation group), and continuous vibration in addition to internal fixation of metatarsal fracture, or intermittent vibration at 1, 2, 3, 5, 7 and 17-day interval in addition to internal fixation of metatarsal fracture (the vibration group). Vibration was done at frequency F=35 Hz, acceleration a=0.25g, 15 min each time 2 weeks after bone fracture. Bone healing was evaluated by micro-CT scan, bone microstructure and mechanical compression of finite element simulation.Results:Intermittent vibration at 7-day interval significantly improved bone fracture healing grade. However, no significant changes on microstructure parameters and mechanical properties were observed among sheep receiving vibration at different intervals.Conclusions:Clinical healing effects should be the top concern. Quantitative analyses of bone microstructure and of finite element mechanics on the process of fracture healing need to be further investigated.
Highlights
Fracture healing is a complex process that involves the coordination of a sequence of biological events, and is delayed in approximately 5-10% of bone fractures due to various causes[1,2]
We evaluated the effects of intermittent vibration on fracture healing by micro-CT and carried out finite element analysis to explore the optimal cycles with various vibration intermittences for fracture healing
There was no significant difference in fracture healing levels among different groups (Table 1)
Summary
Fracture healing is a complex process that involves the coordination of a sequence of biological events, and is delayed in approximately 5-10% of bone fractures due to various causes[1,2]. Efforts have been made to shorten healing time, and improve healing quality. During t bone development and growth, the size, shape and intensity of the bone largely depend on mechanical stimulation, the responses to which could promote bone modeling and remodeling[3]. Low-load mechanical vibration has been reported to increase bone mass, promote bone growth, and enhance fracture healing. Mechanical vibration significantly increased torsional stiffness and energy absorption of rabbit tibial bone during fracture healing, and improved callus formation and other mechanical features of fracture healing in sheep tibial bone[4,5,6,7]. Tibial fractures in patients healed faster with axial vibration than those without[8]
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