Abstract
BackgroundIntermittent theta burst stimulation (iTBS) is a form of repetitive transcranial stimulation that has been used to enhance upper limb (UL) motor recovery. However, only limited studies have examined its efficacy in patients with chronic stroke and therefore it remains controversial.MethodsThis was a randomized controlled trial that enrolled patients from a rehabilitation department. Twenty-two patients with first-ever chronic and unilateral cerebral stroke, aged 30–70 years, were randomly assigned to the iTBS or control group. All patients received 1 session per day for 10 days of either iTBS or sham stimulation over the ipsilesional primary motor cortex in addition to conventional neurorehabilitation. Outcome measures were assessed before and immediately after the intervention period: Modified Ashworth Scale (MAS), Fugl-Meyer Assessment Upper Extremity (FMA-UE), Action Research Arm Test (ARAT), Box and Block test (BBT), and Motor Activity Log (MAL). Analysis of covariance was adopted to compare the treatment effects between groups.ResultsThe iTBS group had greater improvement in the MAS and FMA than the control group (η2 = 0.151–0.233; p < 0.05), as well as in the ARAT and BBT (η2 = 0.161–0.460; p < 0.05) with large effect size. Both groups showed an improvement in the BBT, and there were no significant between-group differences in MAL changes.ConclusionsThe iTBS induced greater gains in spasticity decrease and UL function improvement, especially in fine motor function, than sham TBS. This is a promising finding because patients with chronic stroke have a relatively low potential for fine motor function recovery. Overall, iTBS may be a beneficial adjunct therapy to neurorehabilitation for enhancing UL function. Further larger-scale study is warranted to confirm the findings and its long-term effect.Trial registrationThis trial was registered under ClinicalTrials.gov ID No. NCT01947413 on September 20, 2013.
Highlights
Intermittent theta burst stimulation is a form of repetitive transcranial stimulation that has been used to enhance upper limb (UL) motor recovery
Intermittent Theta burst stimulation (TBS), may hold more promise; we investigated its efficacy in the neurorehabilitation of UL dysfunction
These findings suggest that Intermittent theta burst stimulation (iTBS) combined with conventional neurorehabilitation reduces spasticity and improves UL motor function, but not activities of daily living (ADL), in patients with chronic stroke
Summary
Intermittent theta burst stimulation (iTBS) is a form of repetitive transcranial stimulation that has been used to enhance upper limb (UL) motor recovery. It is estimated that 55–75% of post-stroke patients experience upper limb (UL) functional limitation [2]. Recent studies have shown controversial effects of TBS on UL function in patients with chronic stroke [11,12,13,14,15,16]. Based on the interhemispheric competition model, transcallosal inhibitory signals from the contralesional hemisphere hamper recovery of motor function post stroke [17], while cortical hyperexcitability in the contralesional hemisphere decreases with time after stroke [18] and may limit the effect of cTBS during the chronic stage. ITBS was selected in this study to comprehensively elucidate its efficacy for the treatment of UL dysfunction in patients with chronic stroke
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