Abstract
11The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia, 2Department of Medicine, University of Melbourne, Parkville, Victoria, Australia,3Barcelona Centre for International Health Research (CRESIB), Barcelona, Spain, 4Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea
Highlights
One approach to help reduce the burden of malaria caused by Plasmodium falciparum is intermittent preventive treatment (IPT), which involves periodic therapeutic doses of antimalarials to reduce the incidence of malaria and prevalence of anemia [1,2]
Since malaria is a major cause of illness and death of children under 5 years [7], recent studies have evaluated the potential for using IPT during childhood [8,9,10], including three new papers in PLoS Medicine that add to the growing evidence base [11,12,13]
intermittent preventive treatment during childhood (IPTc) appears to be highly effective at reducing clinical malaria episodes in children under 5 with protective efficacy against symptomatic malaria of 69% or higher [8,9,10]
Summary
One approach to help reduce the burden of malaria caused by Plasmodium falciparum is intermittent preventive treatment (IPT), which involves periodic therapeutic doses of antimalarials to reduce the incidence of malaria and prevalence of anemia [1,2]. IPT seeks to balance these factors by providing treatments that are frequent enough to have significant benefit, without the downsides of chemoprophylaxis. It appears to act in part by post-treatment prophylactic effects [4], while drug levels remain above inhibitory concentrations; long-acting drugs such as sulfadoxinepyrimethamine (SP) and amodiaquine (AQ) have been widely used. Since malaria is a major cause of illness and death of children under 5 years [7], recent studies have evaluated the potential for using IPT during childhood (known as IPTc) [8,9,10], including three new papers in PLoS Medicine that add to the growing evidence base [11,12,13]
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