Abstract
BackgroundMenopause-induced decline in estrogen levels in women is a main factor leading to osteoporosis. The objective of this study was to investigate the effect of intermittent parathyroid hormone (PTH) on bone structural parameters of the femoral neck in ovariectomized rats, in addition to correlations of maximum fracture force.MethodsFifteen female Wister rats were divided into three groups: (1) control group; (2) ovariectomized (OVX) group; and (3) OVX + PTH group. All rats were then killed and the femurs extracted for microcomputed tomography scanning to measure volumetric bone mineral density (vBMD) and bone structural parameters of the femoral neck. Furthermore, the fracture forces of femoral neck were measured using a material testing system.ResultsCompared with the control and OVX + PTH groups, the OVX group had significantly lower aBMD, bone parameter, and mechanical strength values. A comparison between OVX and OVX + PTH groups indicated that PTH treatment increased several bone parameters. However, the OVX + PTH groups did not significantly differ with the control group with respect to the bone structural parameters, except for trabecular bone thickness of cancellous bone, which was greater. In addition, among the bone structural parameters, the CSA and BSI of cortical bone were significantly correlated with the maximum fracture force of the femoral neck, with correlations of, respectively, 0.682 (p = 0.005) and 0.700 (p = 0.004).ConclusionIntermittent PTH helped treat ovariectomy-induced osteoporosis of cancellous bone and cortical bone in the femoral necks of rats. The ability of the femoral neck to resist fracture was highly correlated with the two parameters, namely cross-sectional area (CSA) and bone strength index (= vBMD × CSA), of cortical bone in the femoral neck and was less correlated with aBMD or other bone structural parameters.
Highlights
Menopause-induced decline in estrogen levels in women is a main fac‐ tor leading to osteoporosis
Effect on mechanical strength and bone structure parameters by OVX and intermittent parathyroid hormone treatment Table 1 lists the data on the aBMD, bone parameters of the femoral necks and mechanical strength of the three groups of rats
This study focused on how intermittent parathyroid hormone (PTH) treatment changed the cortical bone and cancellous bone structures of the femoral neck and how cortical bone and cancellous bone parameters were correlated with the ability of the femoral neck to resist fracture
Summary
Menopause-induced decline in estrogen levels in women is a main fac‐ tor leading to osteoporosis. Osteoporosis is a common and serious health issue globally [1,2,3,4]. Osteoporosis is serious because continual bone loss results in bone fragility, which, in turn, leads to osteoporotic fracture and subsequent severe pain and difficulty in movement. This decreases the patient’s quality of life. Postmenopausal osteoporosis is common among postmenopausal women; this is because of decreased estrogen levels from decreased ovary function, which results in considerable bone loss, subsequently decreased bone mineral density, and subsequent fragile fractures [6]. Approximately 30% of postmenopausal women are affected by osteoporosis, and approximately 40% of this 30% will have experienced one or more fragility fractures in their remaining lifetime [7,8,9]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
