Abstract
BackgroundIntermittent parathyroid hormone (PTH) can be used to treat osteoporosis of the spine and hip. However, whether it can be used to treat osteoporosis of the mandible is unclear. The purpose of this study was to explore the influence of applying intermittent PTH to ovariectomized rats on the trabecular bone microarchitecture of the mandible and femoral head.MethodsEighteen female rats were divided into three groups: the healthy group, ovariectomized (OVX) group, and OVX + PTH group. The OVX group and OVX + PTH group had an OVX at 8 weeks of age. The OVX + PTH group received intermittent PTH therapy for 12 weeks. The mandibles and femurs of all rats were removed at 20 weeks and were then scanned using microcomputed tomography (micro-CT).ResultsFrom the micro-CT analysis, the trabecular bone microarchitecture of the mandible and femoral head are offered as follows: (1) The bone volume fraction and trabecular thickness in the OVX group were lower than those in the healthy group. (2) The bone volume fraction and trabecular thickness in the OVX + PTH group approximated those in the healthy group.ConclusionThe conclusions of this study regarding the trabecular bone microarchitecture of the mandible and femoral head are offered as follows: (1) The BV/TV and TbTh in the OVX group were lower than those in the healthy group. (2) The BV/TV and TbTh in the OVX + PTH group approximated those in the healthy group, therefore, intermittent PTH displayed high efficacy for treating femoral or mandibular deterioration of bone microstructure resulting from loss of ovarian function. Osteoporosis of the femur or mandible in the rats was ameliorated by intermittent PTH therapy.
Highlights
Intermittent parathyroid hormone (PTH) can be used to treat osteoporosis of the spine and hip
(2) The Bone volume fraction (BV/TV) and trabecular bone thickness (TbTh) in the OVX + PTH group approximated those in the healthy group, intermittent PTH displayed high efficacy for treating femoral or mandibular deterioration of bone microstructure resulting from loss of ovarian function
Osteoporosis of the femur or mandible in the rats was ameliorated by intermittent PTH therapy
Summary
Intermittent parathyroid hormone (PTH) can be used to treat osteoporosis of the spine and hip. Whether it can be used to treat osteoporosis of the mandible is unclear. The purpose of this study was to explore the influence of applying intermittent PTH to ovariectomized rats on the trabecular bone microarchitecture of the mandible and femoral head. According to the World Health Organization (WHO), women are considered to have osteoporosis if their bone mineral density (BMD) is less than or equal to 2.5 standard deviations of the mean BMD of female adults according to dual-energy X-ray absorptiometry (DXA) measurements [1]. Fragility fractures mainly occur in parts of body that contain more trabecular bones (e.g., the spine, wrist, and hip) [4]
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