Abstract
Intermittent parathyroid hormone (PTH) administration is known to promote bone healing after surgical procedures. However, the mechanism and influence of PTH on the mineral and collagen quality of the jaw are not well understood. Most studies have focused on analyzing the bone density and microstructure of the mandible, and have insufficiently investigated its mineral and collagen quality. Oxidative stress activates osteoclasts, produces advanced glycation end products, and worsens mineral and collagen quality. We hypothesized that PTH induces oxidation and affects the mineral and collagen quality of newly formed mandibular bone. To test this, we examined the mineral and collagen quality of newly formed mandibular bone in rats administered PTH, and analyzed serum after intermittent PTH administration to examine the degree of oxidation. PTH administration reduced mineralization and worsened mineral and collagen quality in newly formed bone. In addition, total anti-oxidant capacity in serum was significantly decreased and the oxidative-INDEX was increased among PTH-treated compared to vehicle-treated rats, indicating serum oxidation. In conclusion, intermittent administration of PTH reduced mineral and collagen quality in newly formed mandibular bone. This effect may have been induced by oxidation.
Highlights
Intermittent parathyroid hormone (PTH) administration is known to promote bone healing after surgical procedures
We examined the mineral and collagen quality of newly formed mandibular bone in rats administered PTH, and analyzed serum after intermittent PTH administration to examine the degree of oxidation
Www.nature.com/scientificreports which are formed by endochondral ossification[6,7], intermittent administration of PTH improves bone density and the structural characteristics of newly formed uninjured skull and jaw bone, which is formed by intra-membranous ossification[8,9]
Summary
Intermittent parathyroid hormone (PTH) administration is known to promote bone healing after surgical procedures. To determine the effect of PTH on calcification of new bone in the mandible, the BMD in newly formed mandibular bone (Fig. 3e) was measured using pQCT after treatment. This analysis indicated that newly formed mandibular bone in PTH rats had reduced mineralization and a deterioration in mineral and collagen quality compared to OVX rats.
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