Abstract
Intermittent Hypoxia Severity in Animal Models of Sleep Apnea.
Highlights
Specialty section: This article was submitted to Respiratory Physiology, a section of the journal Frontiers in Physiology
Given the major health care burden posed by Obstructive sleep apnea (OSA) and the ethical impossibility of carrying out precise mechanistic studies focused on causality in patients with OSA, considerable efforts have been preferentially focused on animal models of OSA (Davis and O’Donnell, 2013; Chopra et al, 2016) and more on those mimicking intermittent hypoxemia
The conventional setting for subjecting animals to intermittent hypoxia consists of cyclically changing the oxygen fraction (FiO2) in the environmental gas breathed by the animals from room air (FIO2 - 21%) to different nadir values ranging from FIO2 of 4 to 15%, and model different degrees of hypoxia severity which, as would be anticipated, yield dose-response effects (Nagai et al, 2014; Lim et al, 2016; Gallego-Martin et al, 2017; Docio et al, 2018)
Summary
Specialty section: This article was submitted to Respiratory Physiology, a section of the journal Frontiers in Physiology. To realistically model intermittent hypoxemia in OSA it is important to bear in mind that the potential effect of this exposure depends on the magnitude of the decrease in arterial oxygen partial pressure (PaO2), since this biological variable de facto determines the PO2 gradient across the capillary membrane, and oxygen delivery to cells within the various tissues.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
