Abstract
BackgroundTo determine whether intermittent hypoxia (IH) can reduce the infarct size (IS) after acute myocardial infarction (AMI) in rats.MethodsArticles were identified in PubMed, EMBASE and the Web of Science and were included if they evaluated the effect of IH on the changes in the infarcted area after AMI in rats.ResultsA preliminary search identified 3633 articles and 29 data sets from 23 articles (12 in vivo, 16 in vitro). The IS decreased after AMI in IH rats both in vitro (SMD -1.46, 95% CI [− 2.37, − 0.55]; I2 = 85.6%, P = 0.000) and in vivo (SMD -1.43, 95% CI [− 2.05, − 0.82], I2 = 73.6%, P = 0.000). Sensitivity analysis indicated that IH had a strong protective effect against myocardial infarction, and the hypoxia concentration was significantly correlated with the change in IS after AMI.ConclusionIH can reduce IS after AMI in rats. This effect of IH may be related to the dose of hypoxia, and the oxygen concentration may be one of the most important influencing factors.
Highlights
To determine whether intermittent hypoxia (IH) can reduce the infarct size (IS) after acute myocardial infarction (AMI) in rats
The search included literature that investigated the effect of IH on infarct size in either in vivo and in vitro models after AMI
Meta-analysis The meta-analysis showed that IH reduced IS after AMI both in vitro group (SMD -1.46, 95% confidence intervals (CI) [− 2.37, − 0.55]; I2 = 85.6%, P = 0.000; Fig. 2) and in vivo group (SMD -1.43,CI [− 2.05, − 0.82], I2 = 73.6%,P = 0.000; Fig. 3)
Summary
To determine whether intermittent hypoxia (IH) can reduce the infarct size (IS) after acute myocardial infarction (AMI) in rats. An increasing number of studies show that IH can help reduce the area of myocardial infarction in patients with coronary heart disease [5,6,7] or in animal models of acute myocardial infarction [8, 9]. IH can reduce IS and increase the ejection fraction of the heart and reduce the occurrence of arrhythmia after AMI [8, 10, 11], IH has protective effects on other organs of the body, such as lowering blood pressure, improving glucose tolerance, improving blood lipid levels, reducing the infarct area after acute cerebral infarction, and improving cognitive dysfunction and renal fibrosis after ischemia [1, 2, 12,13,14,15]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
