Abstract
We attempted to confirm whether intermittent high-dose oral 1,25-dihydroxyvitamin D3 (PULSE) suppressed parathyroid hormone (PTH) secretion, inhibited parathyroid cell proliferation, and increased bone mass in uremic patients (Pts). Twenty two long-term hemodialysis Pts with secondary hyperparathyroidism were given 3.4±0.8µg 1,25 dihydroxyvitamin D3 twice a week for 9.5±3.3 M. The size of parathyroid gland (PT) was estimated by echography and computed tomography every 3 months. Bone mineral density of the radius (BAD) was measured by single photon absorptiometer (Norland SPA 26).
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