Abstract

Injection of Intermediate product I (P-I) resulting from prothrombin proteolysis by thrombin, into the systemic circulation of frog leads to mobilization of the anticoagulating and fibrinolytic potential of the organism. No effect is observed in animals with destroyed central nervous system. Perfusion of humorally isolated carotid labyrinth of frog by P-I considerably increases the bioelectric activity of carotid chemoreceptors and induces changes in blood coagulability in the systemic circulation. The resulting changes are accompanied by an increase in total coagulation time, overall fibrinolytic activity and non-enzymic fibrinolysis. The data obtained are indicative of reflex excitation of the anticoagulating system by P-I, which possesses no coagulating activity, but is structurally similar to thrombin.

Full Text
Published version (Free)

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call