Abstract

In an analysis of intermediate filament protein expression of spindle cell carcinoma, a variant of squamous cell carcinoma, occurring in larynx and tongue, vimentin positivity was found in sarcomatoid areas in 12 of 13 patients. Scattered expression of keratin was observed in sarcomatoid areas in tumours of 10 patients. However, large parts of sarcomatoid areas of such tumours were negative for keratin. Overlying dysplastic epithelium and squamous cell carcinoma components were positive for keratin. In a number of cases there was a strong indication of co-expression of keratin and vimentin in parts of cells that, on histological grounds, belong to sarcomatoid areas or to cells in the interface between carcinoma and spindle cell area. The use of keratin and vimentin type intermediate filament antibodies could be of great help for the correct classification of these tumours.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.