Abstract
Ischemic stroke after cerebral artery occlusion is one of the major causes of chronic disability worldwide. Interleukins (ILs) play a bidirectional role in ischemic stroke through information transmission, activation and regulation of immune cells, mediating the activation, multiplication and differentiation of T and B cells and in the inflammatory reaction. Crosstalk between different ILs in different immune cells also impact the outcome of ischemic stroke. This overview is aimed to roughly discuss the multiple roles of ILs after ischemic stroke. The roles of IL-1, IL-2, IL-4, IL-5, IL-6, IL-8, IL-9, IL-10, IL-12, IL-13, IL-15, IL-16, IL-17, IL-18, IL-19, IL-21, IL-22, IL-23, IL-32, IL-33, IL-34, IL-37, and IL-38 in ischemic stroke were discussed in this review.
Highlights
Ischemic stroke after cerebral artery occlusion is one of the major causes of chronic disability worldwide, and there is still a lack of effective methods to improve functional recovery after cerebral stroke [1]
These findings indicate that IL-6 may be a predictor of the prognosis of ischemic stroke patients
A meta-analysis exploring the relationship between IL-10 gene polymorphism and ischemic stroke risk revealed no overall significant association of IL-10 with ischemic stroke risk, but an association was found with macrovascular disease and microvascular disease [71], demonstrating that certain subtypes of ischemic stroke are correlated to IL-10 gene polymorphisms
Summary
Ischemic stroke after cerebral artery occlusion is one of the major causes of chronic disability worldwide, and there is still a lack of effective methods to improve functional recovery after cerebral stroke [1]. Inflammatory interactions at the blood-endothelial interface, including adhesion molecules, cytokines, chemokines and white blood cells, are crucial for the pathogenesis of tissue injury in cerebral infarction [2]. IL, refers to a lymphocyte medium that interacts between white blood cells or immune cells. It is a cytokine in the same category as blood cell growth factor. Both IL and hemocyte growth factor belong to cytokines, and they coordinate and interact with each other to complete hematopoiesis and immune regulation functions together. This review is to discuss the inflammatory effects of IL in the pathogenesis of stroke, the interactions between different IL-mediated pathways, Interleukin Family in Ischemic Stroke the cell-type dependent effects of different mediators and how different ILs regulate complex inflammatory cascades. The role of IL-1, IL-4, IL-6, and IL-10 were discussed in more detail
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