Interleukins 4 and 13 Induce Exon Skipping of Mutant Dystrophin Pre-mRNA to Restore Dystrophin Production

Abstract

Duchenne Muscular Dystrophy is (DMD) a lethal muscle degenerative disease caused by nonsense or out of frame deletion mutations in the DMD gene [1], which encodes Dystrophin [2,3]. While multiple therapeutic strategies to ameliorate the disease symptoms are under development, there is currently no cure