Interleukin-6, tumor necrosis factor-a and interleukin -10 polymorphisms associated with the cytokines serum levels of hepatitis C virus infection in Brazilian Population

Abstract

Event Abstract Back to Event Interleukin-6, tumor necrosis factor-α and interleukin -10 polymorphisms associated with the cytokines serum levels of hepatitis C virus infection in Brazilian Population Andrea M. Tarrago1, Allyson G. Costa1, João Paulo D. Pimentel2, Samara Tatielle M. Gomes3, Felipe B. Freitas3, Pritesh Lalwani1, Ana Ruth S. Araújo1, Flamir Victória4, Marilu B. Victoria4, Antonio C. Vallinoto3, Aya Sadahiro1* and Adriana Malheiro1* 1 Universidade Federal do Amazonas, Brazil 2 Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas, Brazil 3 Universidade Federal do Pará, Brazil 4 Fundação de Medicina Tropical do Amazonas, Brazil We investigated the effects of polymorphisms in Interleukin-6, tumor necrosis factor-α and interleukin-10 in chronic hepatitis C before they start the treatment in Manaus, Amazonas, Brazil. A total of 116 individual were genotyped for the genes encoding -174IL6, -308TNFα, and -1082IL10 and the IL-2, IL-4, IL-6, IL-10, TNF-α, IFN-γ and IL17A were measured. The aim of this study was to evaluate the influence of polymorphisms: -308TNFα, -174IL6 and -1082 IL10 on the cytokine profile TH1, TH2 and TH17, in samples from patients with chronic hepatitis C and blood donors’ candidates. A total of 116 subjects were investigated, 69 HCV+ and 47 controls. The cytokines IL-2, IL-6, IFN-γ, IL-17A, showed to be increased in HCV+ patients compared to controls. The IL-10 levels were higher in the control group compared to HCV + patients. Patients with genotype GA for -308TNFα showed higher TNF-α levels compared with control subjects. It was also observed that patients HCV+ with genotypes GG and GC for IL-6 had a higher serum levels of IL-6 compared to controls, and there were not observed significant associations between -1082IL10 of genotype frequencies and the cytokines serum levels in patients HCV+. The results suggest a possible influence of polymorphisms of TNF-α, IL-6 and IL-10 on the production and release of the cytokines. Acknowledgements CNPq, FAPEAM, CAPES, HEMOAM, FMT-AM and INPA Keywords: IL-10, IL-6, Polymorphism, Genetic, Hepatitis C, Cytokines Conference: 15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013. Presentation Type: Abstract Topic: Immune-mediated disease pathogenesis Citation: Tarrago AM, Costa AG, Pimentel JD, Gomes SM, Freitas FB, Lalwani P, Araújo AS, Victória F, Victoria MB, Vallinoto AC, Sadahiro A and Malheiro A (2013). Interleukin-6, tumor necrosis factor-α and interleukin -10 polymorphisms associated with the cytokines serum levels of hepatitis C virus infection in Brazilian Population. Front. Immunol. Conference Abstract: 15th International Congress of Immunology (ICI). doi: 10.3389/conf.fimmu.2013.02.01085 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 29 Jun 2013; Published Online: 22 Aug 2013. * Correspondence: Prof. Aya Sadahiro, Universidade Federal do Amazonas, manaus, Brazil, asadahiro@uol.com.br Prof. Adriana Malheiro, Universidade Federal do Amazonas, manaus, Brazil, malheiroadriana@yahoo.com.br Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Andrea M Tarrago Allyson G Costa João Paulo D Pimentel Samara Tatielle M Gomes Felipe B Freitas Pritesh Lalwani Ana Ruth S Araújo Flamir Victória Marilu B Victoria Antonio C Vallinoto Aya Sadahiro Adriana Malheiro Google Andrea M Tarrago Allyson G Costa João Paulo D Pimentel Samara Tatielle M Gomes Felipe B Freitas Pritesh Lalwani Ana Ruth S Araújo Flamir Victória Marilu B Victoria Antonio C Vallinoto Aya Sadahiro Adriana Malheiro Google Scholar Andrea M Tarrago Allyson G Costa João Paulo D Pimentel Samara Tatielle M Gomes Felipe B Freitas Pritesh Lalwani Ana Ruth S Araújo Flamir Victória Marilu B Victoria Antonio C Vallinoto Aya Sadahiro Adriana Malheiro PubMed Andrea M Tarrago Allyson G Costa João Paulo D Pimentel Samara Tatielle M Gomes Felipe B Freitas Pritesh Lalwani Ana Ruth S Araújo Flamir Victória Marilu B Victoria Antonio C Vallinoto Aya Sadahiro Adriana Malheiro Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. 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