Abstract
BackgroundAllergic rhinitis is a widespread disorder across the globe. The Shirazi thyme (Zataria multiflora) has been shown to have considerable antioxidant and anti-inflammatory properties. This study assessed the effect of this herbal product on alterations in inflammatory/anti-inflammatory cytokines.MethodThis study was conducted on the bank sample before and after the intervention to measure interleukin-4, interleukin-5, and interferon -γ levels with the ELISA test method in a supernatant taken from the PBMC cell culture from 30 allergic rhinitis patients.ResultsThe IL-4 level had no significant difference between the two groups before the treatment. However, it had a significant increase in the case group after the treatment. The IL-5 level was significantly higher in the case group before the treatment. Nevertheless, there were no significant differences between the case and control groups after the treatment. Similarly, no significant differences were observed between the two groups considering IFN-γ before and after the treatment.ConclusionConsuming thyme with an increase in anti-inflammatory cytokine IL-4 and a decrease in IL-5 cytokine control inflammation and improvement in allergic rhinitis symptoms.Clinical trial details This clinical trial study was recorded at 22.5.2014 in the Iran Registry of Clinical Trials code: (IRCT2016121823235N6) https://www.irct.ir/trial/19852
Highlights
Allergic rhinitis is a highly prevalent inflammatory disorder of the nasal mucosa with symptoms including nose itching, rhinorrhea, sneezing, and a congested nose, and disabling effects
The IL-4 level had no significant difference between the two groups before the treatment
The IL-5 level was significantly higher in the case group before the treatment
Summary
Allergic rhinitis is a highly prevalent inflammatory disorder of the nasal mucosa with symptoms including nose itching, rhinorrhea, sneezing, and a congested nose, and disabling effects. The. On the one hand, the production and increase of specific allergen IgE is a typical laboratory manifestation in atopic allergic rhinitis [4]. Main cytokines interleukin-4 (IL-4), interleukin-5 (IL-5), and interleukin-13 play a critical role in the production of atopic allergic rhinitis [5], and along with IFN-y, cause continuous allergic. Zataria multiflora, commonly called Shirazi thyme, is a local herb found in Iran and other parts of the Middle East. The plant’s extract contains phenolic compounds (thymol and carvacrol) and the main non-phenolic compound, which all have proven antioxidant and anti-inflammatory effects such as irritable bowel syndrome, infectious diseases and bronchitis [7]. The Shirazi thyme (Zataria multiflora) has been shown to have considerable antioxidant and anti-inflammatory properties. This study assessed the effect of this herbal product on alterations in inflammatory/anti-inflammatory cytokines
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