Abstract
BackgroundInterleukin (IL)-13, a T-helper type 2 cytokine, plays a critical role in the development of chronic obstructive pulmonary disease (COPD). This meta-analysis was performed to assess the association of IL-13 −1112 C/T promoter polymorphism with COPD susceptibility.MethodsPublished case-control studies from Pubmed and China National Knowledge Infrastructure (CNKI) databases were retrieved. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated.ResultsEight case-control studies in seven articles were included in this meta-analysis. Pooled effect size showed IL-13 −1112 C/T was associated with COPD susceptibility in a codominant genetic model (TT vs CT, OR: 1.82, 95% CI: 1.14–2.92 and TT vs CC, OR: 2.02, 95% CI: 1.10–3.72), indicating individuals with TT genotype had an increased risk for COPD compared with those with CT or CC genotype. According to ethnicity, results indicated IL-13 −1112 C/T was correlated with COPD susceptibility in Arabians (TT vs CT, OR: 2.94, 95% CI: 1.03–8.42 and TT vs CC, OR: 3.05, 95% CI: 1.08–8.59). Moreover, after excluding the study without Hardy-Weinberg equilibrium, the pooled results were robust and no publication bias was found in this study.ConclusionsThis meta-analysis suggests IL-13 −1112 C/T promoter polymorphism is associated with the risk of COPD in Arabians.
Highlights
Interleukin (IL)-13 is a T-helper type 2 (Th2) cytokine and its gene position is together with the IL-4 gene located within 15 kb on chromosome 5q31, a region associated with asthma, airway hyper-responsiveness and IgE levels [1]
Van der Pouw Kraan et al firstly suggested an association of the changes from cytosine to thymine at 21112 C/T in a promoter region associated with altered regulation of IL-13 production in chronic obstructive pulmonary disease (COPD) [8]
In the subgroup analysis by ethnicity, results indicated IL-13 21112 C/ T was correlated with COPD susceptibility in Arabians (TT vs CT, odds ratios (OR): 2.94, 95% confidence intervals (CI): 1.03–8.42 and TT vs CC, OR: 3.05, 95% CI: 1.08–8.59)
Summary
Interleukin (IL)-13 is a T-helper type 2 (Th2) cytokine and its gene position is together with the IL-4 gene located within 15 kb on chromosome 5q31, a region associated with asthma, airway hyper-responsiveness and IgE levels [1]. Increased IL-13 expression was detected in peripheral blood of COPD subjests and bronchial submucosa in smokers with chronic bronchitis [3,4]. These data indicated a critical role of IL-13 in COPD. Interleukin (IL)-13, a T-helper type 2 cytokine, plays a critical role in the development of chronic obstructive pulmonary disease (COPD). This meta-analysis was performed to assess the association of IL-13 21112 C/T promoter polymorphism with COPD susceptibility
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