Interleukin10 rs1800896 and interleukin1B rs16944 polymorphisms and the risk of cervical cancer.

Abstract

The purpose of this study was to evaluate the relationships between interleukin10 (IL10) (rs1800896) and interleukin1B (IL1B) (rs16944) genetic polymorphisms and the risk for cervical cancer in acohort of women from Croatia. Acase-control study of 81patients with cervical cancer and 80age-matched healthy controls was performed. We collected peripheral blood samples, extracted deoxiribonucleic acid (DNA), and analyzed two single-nucleotide polymorphisms (SNPs) rs1800896 and rs16944 using TaqMan assays (Fa. Thermo Fisher Scientific, Waltham, MA, USA) and real-time polymerase chain reaction (PCR). We investigated apossible association between two cytokine genetic polymorphisms and the occurrence of cervical cancer. Our results showed no significant difference in the frequency of IL10 (rs1800896) and IL1B (rs16944) genotypes between the patients and the controls (χ2 test, P < 0.05). In this study, no association was found between IL10 rs1800896 and IL1B rs16944 polymorphisms and cervical cancer development.