Abstract
AbstractObjectiveInterleukin (IL)‐17 produced by T helper (Th)17 cells is considered to be accepted by the IL‐17 receptor expressed by the airway epithelium, thereby influencing the migration of neutrophils by inducing the production of IL‐8, a neutrophil migration chemokine. However, it was recently reported that Th17 cells show marked production of IL‐8. Our previous studies showed that Th17 cell differentiation is governed by dopamine signals. We therefore analyzed the role of dopamine signals in IL‐8 production.MethodsWe cocultured dopamine D2‐like receptor agonists and an antagonist with peripheral blood mononuclear cells isolated from the peripheral blood of healthy human volunteers, as well as cloned Th cells established from peripheral blood mononuclear cells. We then determined the levels of IL‐8.ResultsCloned Th1 and Th17 cells, but not Th2 cells, showed marked production of IL‐8. Interferon‐γ and IL‐17 levels, but not those of IL‐5, showed a positive correlation with IL‐8 levels. The IL‐8 production of activated T cells was augmented by a dopamine D2‐like receptor antagonist and suppressed by dopamine D2‐like receptor agonists.ConclusionsThe dopamine signal is not only a differentiation induction factor of Th17, but is also involved in IL‐8 production from activated T cells. It is suppressed by dopamine D2‐like receptor agonists, which are known to ameliorate Parkinson's disease.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
