Abstract
Various vitreous soluble factors other than VEGF accumulate in angiogenic retinopathies like retinopathy of prematurity. However, only VEGF signaling is currently targeted clinically. Interluekin-8 (IL-8)'s vitreous levels correlate with disease severity in angiogenic retinopathies. IL-8 is a pro-angiogenic chemokine linked to diseases in other organ systems. We hypothesize that manipulating IL-8 signaling can alter retinal vascularization.
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Schedule a callMore From: Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus
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