Abstract
Obesity is a nutritional disease characterized by excess of adipose tissue. It is recognized as a low-grade chronic inflammation state characterized by increased serum levels of acute phase proteins such as interleukins (ILs) and cytokines. IL-6 is a proinflammatory cytokine, which is involved in the regulation of lipid metabolism associated with obesity and inflammation. It plays numerous proinflammatory roles. However, IL-6 may also play an anti-inflammatory role. Matrix metalloproteinases (MMPs) participate in several physiological processes such as remodeling of extracellular matrix (ECM), healing, angiogenesis and apoptosis. They are regulated by specific tissue inhibitors (TIMPs) which block access to the active site of MMPs. A dual role for MMP-8 has been described under specific conditions: MMP-8 plays a role in the development of the inflammatory response but appears to play an anti-inflammatory role during recovery and may be crucial for this process.
Highlights
Obesity is a nutritional disorder characterized by excess of adipose tissue
The evaluation of the correlation between the levels of Matrix metalloproteinases (MMPs)-8 and Interleukin 6 (IL-6) presented a moderate positive correlation was found between MMP-8 and IL-6 serum levels (r= 0,4510; p≤0.05), being the results statistically significant (Figure 7)
A weak correlation was observed between IL-6 levels and visceral fat mass percentage (r = 0,2887; p = 0,0832) (Figure 6). These results may be related to the fact that adipose tissue is endocrine and produces numerous factors that contribute to systemic inflammation [29]
Summary
Obesity is a nutritional disorder characterized by excess of adipose tissue The development of this disorder is associated with coordinated cellular processes, including adipocyte hypertrophy followed by recruitment of adipocyte precursors, and new fat cell differentiation. These processes are accompanied by neovascularization, which is essential for generation and function of the tissue [1]. The development of obesity involves processes like adipogenesis and extracellular matrix (ECM) remodeling [2]. This disorder is recognized as a low-grade chronic inflammatory state, characterized by the increase of serum levels of acute phase proteins, such as C-reactive protein (CRP), and other interleukins and cytokines [3]. The rapid expansion of the adipose tissue may produce intrinsic signals which might trigger an inflammatory response
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