Interleukin-6 (IL-6) Gene Polymorphism Patients with Type 2 Diabetes in Thi-Qar Province

Abstract

This study was conducted in the Biotechnology Research Unit, Mazaya University College, for the period from January to March 2021. This study includes 150 participants (100 T2DM patients and 50 healthy as a control group). Through the analysis of the results, it was found that the highest incidence of type 2 diabetes was in patients whose duration of illness ranged from (1-4) years and reached 70%, clear significant difference (P.Value = 0.00**). The results of the study analysis also showed that there was no significant difference between the two groups of patients and the comparison according to the interleukin levels, where the value of (P-value =0.41). The results of the analysis of the study through the analysis of genotypes and phenotypes showed that there was no significant difference between the two groups of patients and the comparison, where the value of (P.Value = 0.917). In this study, 25% of patients have GG genotype however 61% have GC genotype without significant difference between patients and control group (OR=1.10). While the frequency of the CC genotype was 14%, There is a clear significant difference between the group of patients and the comparison group (OR=1.56*). Mutations in the IL-6 gene were recorded in the gene bank with accession numbers. LC656471, LC656472, LC656473, LC656474, LC656475, LC656476, LC656477.