Abstract
Atrial fibrillation (AF) progresses after coronary bypass grafting in 11–40% of patients. Plasma biomarkers such as interleukin 6 (IL-6) can assess the risk of AF development. We performed a systematic review using as sources: PubMed, LILACS, and Cochrane Library databases were investigated using Boolean operators and MeSH terms (Medical Subject Headings Terms) “Atrial Fibrillation AND Interleukin AND Biomarkers”. As the following eligibility criteria: observational studies, studies with coronary artery bypass grafting with plasma levels of IL-6 recorded after screening, 11 articles were selected. Three studies met the inclusion and exclusion criteria. Results: IL-6 levels on AF group - Ishida et al. reported the plasma levels of IL-6 during the post-operative period as 360 ± 143 pg/mL, while Pretorius et al. reported it to be 380.6 ± 151.1 pg/mL. Lastly, Ziabakhsh-Tabari et al. reported a post-operative plasma IL-6 level of 38.2 ± 32 pg/mL. It is considered that new studies about the object are necessary, and these studies should be more standardized. Preferably, it would be important for the daily measurement of IL-6 and its correlation with AF development for statistical analysis to set the best time for sample collection and cut-off value.
Highlights
Atrial fibrillation (AF) develops after coronary bypass grafting in 11–40% of the patients, usually between the second and fifth days after the procedure; this rate can vary based on the definition of AF and the diagnostic protocols used [1,2]
This study aimed to investigate the role of interleukin 6 (IL-6) as a plasma biomarker for predicting AF after coronary bypass grafting
This study found that the mean incidence rate of AF on males was 27.7% and that on females was 23.5%
Summary
Atrial fibrillation (AF) develops after coronary bypass grafting in 11–40% of the patients, usually between the second and fifth days after the procedure; this rate can vary based on the definition of AF and the diagnostic protocols used [1,2]. Plasma biomarkers, such as inflammatory biomarkers, vascular pathology, myocyte damage, atrial fibrosis, and impaired cardiac function, when associated with clinical events such as surgery, have been shown to be relevant for assessing the risk of developing AF. This study aimed to investigate the role of IL-6 as a plasma biomarker for predicting AF after coronary bypass grafting
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