Abstract
Previous studies have established the association between chronic fetal hypoxia and elevated nucleated red blood cells (NRBCs) counts. Animal studies have shown that 4-8 hours of fetal hypoxemia are required before a significant increase in Erythropoietin (EPO) is demonstrated. In contrast, Interleukin (IL)-6 has the capacity to rapidly induce erythroid maturation. Therefore, we set forth to evaluate the role of EPO and IL-6 as potential mediators of elevated fetal NRBC counts in response to acute hypoxia.
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