Abstract
Background: Interleukin (IL)-4 is a member of T helper 2 (Th2) axis produced by T-lymphocyte and mast cell. It has been shown that IL-4 expression changes in tumor tissues. The main objective of this study is to investigate the expression of IL-4 mRNA in patients with Laryngeal Squamous Cell Carcinoma (LSCC) with or without lymph node involvement. Materials and Methods: mRNA expression of IL-4 in LSCC tissues were detected by quantative Real-Time PCR (qRT-PCR). Expression of IL-4 gene was compared between lymph node positive and negative patients with Squamous Cell Carcinoma of Larynx. Results: No statistically significant association was found in expression of IL-4 between lymph node positive and negative patients. Conclusion: It seems that IL-4 has no important effect on the involvement of lymph node in LSCC. However, to achieve a definite conclusion more investigations are certainly required.
Highlights
Laryngeal cancer consists of some types of squamous cell carcinoma (SCC)
As IL-4 is one of the important cytokines known with cancer promoting characteristics such as metastasis to different organs, we aimed to investigate IL-4 gene in tumor tissues of laryngeal cancer patients with and without lymph nodes (LN) involvement
In this study we aimed to evaluate the expression of IL-4 mRNA in tumor tissues of patients with Laryngeal Squamous Cell Carcinoma (LSCC) and its relationship with LN involvement in these patients
Summary
Laryngeal cancer consists of some types of squamous cell carcinoma (SCC). Cytokines would change in different strategic sites such as peripheral blood, lymph nodes (LN) and tissues of patients with cancer. IL-4 has a main role in differentiation of native T lymphocytes and causes the production of IL-4, IL-5, IL-10,and IL-13. These cytokines strongly inhibit the differentiation of interferon gamma (IFNγ) producing cells [6]. The main objective of this study is to investigate the expression of IL-4 mRNA in patients with Laryngeal Squamous Cell Carcinoma (LSCC) with or without lymph node involvement. Expression of IL-4 gene was compared between lymph node positive and negative patients with Squamous Cell Carcinoma of Larynx. To achieve a definite conclusion more investigations are certainly required. [GMJ. 2014;3(1):20-23]
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