Abstract
Anosmia is common in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). Dupilumab, a human IL-4Rα monoclonal antibody that blocks both IL-4 and IL-13 signaling, provides rapid and sustained improvements in sense of smell in patients with CRSwNP via mechanisms not clearly understood. Therefore, we investigated the effects of IL-4 and IL-13 on the mouse olfactory system in vitro and in vivo.
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