Biomedicine & Pharmacotherapy | VOL. 155
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Interleukin-37 ameliorates cigarette smoke-induced lung inflammation in mice

Publication Date Nov 1, 2022

Abstract

Cigarette smoking (CS) is the leading cause of chronic obstructive pulmonary disease, and its severity is closely related to lung inflammation. Interleukin (IL)-37 is a newly discovered member of the IL-1 family with anti-inflammatory activity. Our study aimed to elucidate the effect of IL-37 on CS-induced lung inflammation in mice. In this study, mice were exposed to six cigarettes for 1h three times daily (4h smoke-free intervals) for 10 consecutive days. Mice were treated intranasally with IL-37-expressing lentivirus and empty lentivirus particles 1day before the first CS or sham exposure. Mice were sacrificed on day 11 to evaluate the effect of IL-37 on CS-induced pulmonary inflammation in mice. Administering IL-37-expressing lentivirus significantly reduced CS-induced weight loss in mice compared to empty lentivirus controls (P< 0.05). Histological analysis showed that IL-37 significantly alleviated inflammatory cell recruitment, alveolar septum enlargement, alveolar wall attenuation, mucus hypersecretion, and goblet cell metaplasia in mouse lungs (P<0.001). IL-37 expression also significantly inhibited CS-induced increases in inflammatory cells (including lymphocytes, neutrophils, and macrophages) in mouse lungs (P<0.05), as well as pro-inflammatory cytokines such as IL-1β, IL-6, IL-17, monocyte chemotactic protein-1 and tumor necrosis factor-α production (P<0.05). IL-37 also significantly reduced myeloperoxidase activity in mouse serum (P<0.01) and lung tissues (P<0.001). Therefore, IL-37 can ameliorate CS-induced pul...

Concepts

Mouse Lungs Pulmonary Inflammation In Mice Lung Inflammation In Mice Smoke-induced Lung Inflammation In Mice Activity In Mouse Serum CS-induced Inflammation CS-induced Pulmonary Inflammation CS-induced Lung Inflammation Increases In Inflammatory Cells Tumor Necrosis Factor-α Production

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