Abstract
Interleukin-33 (IL-33) is a cytokine involved in interleukin-1 family. Role of IL-33 in immune system activation is well described in the literature. IL-33 has been identified as an endogenous alarm signal (alarmin) to alert various types of immune cells to trauma. In this narrative review, we aimed to underline the diagnostic and prognostic importance of IL-33 in trauma, particularly in brain trauma.
Highlights
IL-33 is known to be released from damaged cells following trauma
IL-33 released after central nervous system (CNS) injury initiates a local response and a meningeal one through actions of Comment on “ e glia-derived alarmin IL-33
ST2/IL-33 cytokine signaling system has emerged as an intercellular signaling system that participates in processes of the immune response, homeostasis, and tissue injury/ repair
Summary
IL-33 is known to be released from damaged cells following trauma. It is known as an “alarmin” which means an endogenous signal of tissue injury [1]. It is a nuclear-associated cytokine belonging to IL-1 family and well known with the inducer role in type-2 allergic immunity [2]. In central nervous system (CNS), IL-33 activates microglias and macrophages in order to limit glial scarring [3, 4]. We sought the utility of IL-33 in traumatic brain injury (TBI)
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