Abstract
In 2009, several independent studies revealed a strong association between genetic variation in the interleukin-28B (IL28B) locus and the outcome of treatment for chronic infection with hepatitis C virus (HCV). Hundreds of studies followed, and a recent meta-analysis reports more precise odds ratios than previously published for associations between commonly reported IL28B polymorphisms and spontaneous HCV clearance or treatment outcome. These results should facilitate the interpretation of IL28B genotyping as part of personalized treatment approaches.
Highlights
In 2009, several independent studies revealed a strong association between genetic variation in the interleukin-28B (IL28B) locus and the outcome of treatment for chronic infection with hepatitis C virus (HCV)
In 2009, a series of independent genome-wide association studies using high-throughput methods to screen representative single nucleotide polymorphism (SNP) throughout the genome were published [3,4,5]. These studies showed that patients who were infected with HCV genotype 1 were significantly more likely to achieve a sustained virological response with pegylated interferon-α plus ribavirin combination therapy if they had a common variant in the IL28B locus
These reports have since inspired hundreds of studies examining the role of IL28B in HCV infection in other ethnic groups and with other HCV genotypes
Summary
In 2009, several independent studies revealed a strong association between genetic variation in the interleukin-28B (IL28B) locus and the outcome of treatment for chronic infection with hepatitis C virus (HCV). These studies showed that patients who were infected with HCV genotype 1 were significantly more likely to achieve a sustained virological response with pegylated interferon-α plus ribavirin combination therapy if they had a common variant in the IL28B locus (rs12979860 C/C or rs8099917 T/T).
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