Abstract
To study the relationship between cytokines and the development of monocrotaline-induced pulmonary hypertension, monocrotaline was given and interleukin-2 was measured. The amount of interleukin-2 produced by pulmonary cells obtained by bronchoalveolar lavage was high only on the 14th day after monocrotaline injection (p < 0.01). This suggests that many kinds of cells in the monocrotaline-treated rat lung were activated by cytokines, and that these interactions play an important role in the development of monocrotaline-induced pulmonary hypertension in rats.
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