Abstract
Purpose: Interleukin (IL)-17 is a family of 6 cytokines from which the homodimers IL-17A and IL-17F, and the heterodimer IL-17AF are most well-studied. These IL-17-cytokines have a pivotal function in host defence, but have also been linked to several autoimmune and chronic inflammatory diseases due to their ability to stimulate resident fibroblasts to release mediators that contribute to inflammation, angiogenesis, and matrix destruction. In osteoarthritis (OA), increased concentration of IL-17A has been found in synovium, and the IL-17A concentration in synovial fluid and serum has been found to correlate with increased pain, decreased function, and increased disease severity.
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