Abstract
BackgroundInterleukin 17 (IL-17) plays an important role in many autoimmune diseases including neuromyelitis optica (NMO) and multiple sclerosis (MS), which are inflammatory demyelinating diseases of the central nervous system. A large number of non-HLA single nucleotide polymorphisms have been reported to increase the risk of MS. However, their effects on NMO have been less well studied. MethodsFifty-two anti-aquaporin 4 antibody-positive NMO patients, 69 anti-aquaporin 4 antibody-negative conventional MS patients, and 131 controls were genotyped for the IL-17A rs2275913 and IL-17F rs763780 single nucleotide polymorphisms by DNA sequencing. ResultsSignificantly higher frequencies of the rs763780 T allele (puncorr=0.011) and TT genotype (puncorr=0.007, pcorr=0.042) were observed in NMO patients versus controls. ConclusionsThe rs763780 T allele and TT genotype may increase susceptibility to NMO in the Southern Han Chinese.
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