Abstract
Leprosy is a chronic infectious disease caused by Mycobacterium leprae, which is an obligate intracellular bacteria. This study aims to determine the interleukin-12 and interleukin-4 levels of multibacillary leprosy patients before and after Rifampicine Ofloxacine Minocycline (ROM) combined therapy for three months. The research used an analytic observational design with the prospective cohort study pre and post treatment method. The samples were taken at the polyclinic of Skin Treatment Central Public hospital and Ibnu Sina hospital. Samples examination was conducted in the NECHRI laboratory, Hasanuddin University Teaching hospital. The samples were ten new patients of MB type leprosy. Blood samples were taken before and after the ROM therapy for three months. The levels of interleukin-12 and interleukin-4 were assessed using the ELISA technique. The results shows that there is no significant change in the levels of interleukin-12 and interleukin-4 in the patients of multibacillary leprosy before and after ROM therapy for three months.
Highlights
Leprosy is a chronic infectious disease caused by the bacterium Mycobacterium Leprae, an obligate intracellular bacteria
The suspected main source of infection is multibacillary patients, who carry a lot of bacteria on their skin, and capable of transmitting large amounts of bacteria from the nose, with an average of 107 per day [2]
The short follow up duration after treatment in this study which is only three months
Summary
Leprosy is a chronic infectious disease caused by the bacterium Mycobacterium Leprae, an obligate intracellular bacteria. The upper respiratory tract of multibacillary patients (lepromatous and borderline) is a key outlet of the bacterium, which infect others through their upper respiratory tract, especially the nasal mucosa by contaminated droplets [1]. The suspected main source of infection is multibacillary patients, who carry a lot of bacteria on their skin, and capable of transmitting large amounts of bacteria from the nose, with an average of 107 per day [2]. The importance role of the immune system in leprosy is indicated by the clinical manifestations and determined by the host immune system. Host produce both humoral and cellular immunity against M. Leprae but it shows opposite correlation across the spectrum of leprosy and is associated with the number of bacilli [3]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: American Journal of Clinical and Experimental Medicine
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
