Abstract
Interleukin-10 (IL-10) may have both pro- and anti-inflammatory effects in Guillain–Barré syndrome (GBS). The distribution of polymorphisms in the IL-10 gene (−1082 (G/A), −819 (T/C) and −592 (A/C)) was analysed to determine whether they could influence disease susceptibility or clinical course in GBS. The −592 CC and −819 CC genotypes associated with increased IL-10 response were more frequent in the GBS patients than in the controls ( P=0.027), but the polymorphisms did not influence the clinical course of the disease.
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