Abstract
Urticarial rash is a hallmark symptom of autoinflammatory diseases such as Cryopyrin-associated periodic syndrome (CAPS) and Schnitzler's syndrome (SchS). Clinically, the urticarial rash may not be distinguished from the skin symptoms in chronic urticaria patients. As interleukin-1s (IL-1s) has been shown to play a pivotal role in the pathogenesis of CAPS and SchS we here aim at investigating IL-1s and related cytokines for their potential as diagnostic skin biomarkers in patients with urticarial autoinflammatory syndromes.
Highlights
Urticarial rash is a hallmark symptom of autoinflammatory diseases such as Cryopyrin-associated periodic syndrome (CAPS) and Schnitzler’s syndrome (SchS)
The urticarial rash may not be distinguished from the skin symptoms in chronic urticaria patients
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Summary
Urticarial rash is a hallmark symptom of autoinflammatory diseases such as Cryopyrin-associated periodic syndrome (CAPS) and Schnitzler’s syndrome (SchS). The urticarial rash may not be distinguished from the skin symptoms in chronic urticaria patients. As interleukin-1ß (IL-1ß) has been shown to play a pivotal role in the pathogenesis of CAPS and SchS we here aim at investigating IL-1ß and related cytokines for their potential as diagnostic skin biomarkers in patients with urticarial autoinflammatory syndromes
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