Abstract
ObjectiveWe performed a meta-analysis to assess association between interleukin 1 (IL-1) polymorphisms and the risk of Intervertebral Disc Degeneration (IDD).BackgroundA series of studies have investigated the association between common single nucleotide polymorphisms in IL-1 and IDD risk; however, the overall results are inconclusive.MethodsTwo independent investigators conducted a systematic search for relevant available studies. Allele frequencies were extracted from each study. The association between the IL-1α (+889C/T) or IL-1β (+3954C/T) polymorphism and IDD risk was measured by odds ratios (OR) with 95% confidence intervals (95% CI).ResultsFive and six studies, respectively, were ultimately included in the meta-analysis for the IL-1α (+889C/T) and IL-1β (+3954C/T) polymorphism. The combined results showed that the IL-1α (+889C/T) polymorphism was significantly associated with increased susceptibility to IDD, particularly in Caucasians (TT versus CC: OR = 2.95, 95% CI: 1.45, 6.04; Pheterogeneity = 0.82; TT versus CC/CT: OR = 2.29, 95% CI: 1.18, 4.47; Pheterogeneity = 0.20). In contrast, the IL-1β (+3954C/T) polymorphism showed a trend towards increased risk in Caucasians but no association in Asians.ConclusionThis meta-analysis suggested that the IL-1α (+889C/T) polymorphism is significantly associated with risk of IDD, especially in Caucasian populations.
Highlights
Intervertebral disc degeneration (IDD) is a multifactorial disease of the musculoskeletal system [1]
The association between the IL-1α (+889C/T) or IL-1β (+3954C/T) polymorphism and IDD risk was measured by odds ratios (OR) with 95% confidence intervals
The combined results showed that the IL-1α (+889C/T) polymorphism was significantly associated with increased susceptibility to IDD, in Caucasians (TT versus CC: OR = 2.95, 95% confidence intervals (95% confidence intervals (CIs)): 1.45, 6.04; Pheterogeneity = 0.82; TT versus CC/CT: OR = 2.29, 95% CI: 1.18, 4.47; Pheterogeneity = 0.20)
Summary
Intervertebral disc degeneration (IDD) is a multifactorial disease of the musculoskeletal system [1]. Does the risk of lower back pain, disc herniation, and even radiating pain from the sciatic nerve [2]. Because it is a major cause of disability at work, increasing attention has been paid to IDD [3]. The pathogenesis and cause of IDD are not fully elucidated, but epidemiologic studies have suggested that IDD is associated with adverse mechanical, environmental, and genetic factors [4]. Increased expression of proinflammatory cytokines such as matrix metalloproteases has been observed in degenerating discs; inflammatory factors might play an important role in the pathogenesis of IDD [7]. A series of studies have investigated the association between common single nucleotide polymorphisms in IL-1 and IDD risk; the overall results are inconclusive.
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