Abstract

Tumor Immunology Previous studies indicate that a high frequency of intratumoral neutrophils is associated with a poor clinical prognosis. Si et al. used microscopy and imaging techniques to examine how intratumoral interactions between tumor-associated neutrophils (TANs) and tumor-infiltrating lymphocytes (TILs) can affect TIL function. They localized functional cell subsets, which were then used to identify hotspots of TAN-TIL interactions within tumors. Some of these TANs had a distinct phenotype, and their physical association with TILs reduced antitumor functions of those TILs. Sci. Immunol. 4 , eaaw9159 (2019).

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