Abstract
Binary file ES_Abstracts_Final_ECDC.txt matches
Highlights
In Canada, the 2014/15 influenza season has been distinguished by an early and intense epidemic due almost exclusively (> 90%) to influenza A(H3N2) subtype viruses
As annual influenza immunisation campaigns typically commence in October across Canada, and increased influenza virus circulation typically begins in early November, nasal or nasopharyngeal specimens collected from 1 November 2014 were eligible for inclusion in the primary vaccine effectiveness (VE) analysis
A total of 1,192 specimens were submitted within the VE study period, of which 861 (72%) were included in primary VE analyses with collection dates between 3
Summary
In Canada, the 2014/15 influenza season has been distinguished by an early and intense epidemic due almost exclusively (> 90%) to influenza A(H3N2) subtype viruses. All (> 99%) of these A(H3N2) viruses have been characterised as genetically and/or antigenically distinct from the A/Texas/50/2012(H3N2)like (clade 3C.1) vaccine reference strain used for both the current 2014/15 and prior 2013/14 northern hemisphere influenza vaccines [1]. This profile of dominant influenza A(H3N2) activity is in sharp contrast to the 2013/14 season, when an early epidemic peak occurred, but was instead due to predominant but antigenically well-conserved A(H1N1) pdm viruses [2]. Findings are considered in relation to virus-host interactions, notably the effects of influenza vaccination in the previous season on protection by the current season’s vaccine
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