Intergenerational differences in prevalence and association with survival rates of major cardiovascular risk factors

Abstract

The objective: determination of the prevalence of major cardiovascular risk factors (CVRF) and their association with the survival rate of cardiovascular disease (CVD) among generations 1905–1924 and 1925–1944 years of birth.Materials and methods. 384 patient case histories were analyzed from 1905 to 1944 with ischemic heart disease (IHD). According to the year of birth, the patients were divided into 2 groups: 1 group – born in the period 1905–1924 («pre-war» generation), 2 group – from 1925–1944 (a generation of «front-line soldiers»). The diagnosis was established on the basis of examinations, in accordance with the current recommendations for the diagnosis of IHD.Results. There are significant intergroup differences in the frequency and structure of arterial hypertension in the pre-war generation group, the incidence of arterial hypertension (AH) was 64,1%, of which 54,6% is isolated systolic hypertension (ISAH). In the frontline group, the AH frequency reached 74,1%, and ISAG accounted for only 27%. When analyzing the average of low density lipoprotein (LDL) values in the first and second generations, there were no significant differences. However, gender analysis revealed that in both groups of women, the average level of LDL was higher than that of men. The prevalence of elevated LDL in the first generation is higher (98,68%) than in 2 generations (94,12%) (р>0,05). The prevalence of the increased level of glucose in the 1st generation is 4,4%, while in the 2nd generation it increases to 20,6% (p=0,0001). Although the diagnosis of diabetes mellitus is 1,94% in the 1st group and 3,68% in the second group, which indicates a significant increase in the cases of violation of carbohydrate metabolism in the 2nd generation.Conclusion. Also, with a detailed gender analysis within the group, attention is drawn to the distribution of overweight and obese individuals: if in the 1st generation of overweight men there was more (68,85%) than with obesity (31,15%), and women with increased body weight was 40,38%, with obesity 59,62%, then in 2 generations 61,8% of men were overweight and only 37% obese. In women, a mirror trend was observed – 36,1% were overweight and 63,9% were obese. These CWR factors were associated with various indicators of life. in the first generation there was no dependence of survival on the presence of individual CVR factors; in the second, survival was significantly lower in patients with obesity and hypertension.