Abstract
Interfollicular Hodgkin's lymphoma represents an unusual pattern of focal involvement of interfollicular zones by Hodgkin's lymphoma along with florid reactive follicular hyperplasia. It is often mistakenly diagnosed as a reactive change. We report a case of a 36 years old male with persistent lymphadenitis for three years, who was finally diagnosed as Interfollicular Hodgkin's lymphoma after being incorrectly diagnosed as reactive lymphadenitis. This case is reported in view of the unusual pattern of Hodgkin's lymphoma as well as its misdiagnosis as a benign lesion. DOI: http://dx.doi.org/10.3329/bjms.v11i3.11739 Bangladesh Journal of Medical Science Vol. 11 No. 03 July12
Highlights
Interfollicular Hodgkin's lymphoma is a characteristic pattern of lymph node involvement by Hodgkin's lymphoma located between hyperplasic follicles
Interfollicular Hodgkin's lymphoma represents a peculiar pattern of focal involvement of the lymph node by Reed Sternberg cells and its variants rather than a subtype of Hodgkin's lymphoma.[2]
It has been well documented that the earliest areas of lymph node involvement by Hodgkin's lymphoma are the interfollicular regions, immediately adjacent to the follicles.[2, 4]
Summary
Interfollicular Hodgkin's lymphoma is a characteristic pattern of lymph node involvement by Hodgkin's lymphoma located between hyperplasic follicles. There is a combination of follicular hyperplasia with expansion of interfollicular areas by infiltrates containing Reed Sternberg cells (RS) and its variants alongwith small lymphocytes, plasma cells, eosinophils and macrophages.
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