Abstract
To determine the gene expression of IFNAR1, IFNAR2 and MxA protein and the association with IFNβ treatment response in MS patients. MS patients treated with IFNβ had a significant decrease in IFNAR1 and IFNAR2 expression, and a significant increase in MxA compared to non-treated patients and healthy controls. Also, those patients who had a good response to treatment had a significant decrease in IFNAR1 and IFNAR2 expression compared to non-responders, non-treated patients and healthy controls. IFNβ influences the expression of its receptors, and is greater in patients who respond to IFNβ treatment. This down-regulation could be indicative of the response to IFNβ.
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